For hundreds of years cannabis plant have been used for recreational use and as medicine remedies. Research reports from patients with multiple sclerosis (MS) experiencing relief of their spasticity and pain after smoking medical marijuana have promoted testing for potential therapeutic application of cannabis preparations in MS. On January 2010 the first large, multicenter, double-blind, placebo controlled study was conducted evaluating medical marijuana for treatment of pain, spasticity and other symptoms related to MS. Basic evidence together with insights from basic research and animal test experiments there is proof and evidence for the therapeutical employment of cannabis in the treatment of MS related chronic pain. Furthermore, data shows medical marijuana has neuroprotective properties. However, results from university clinical trials do not allow the recommendation for the inclusive use of medical marijuana in MS. This research summarizes experimental research regarding the therapeutic potential of medical marijuana for the treatment of MS.